SMRs and AMRs

Saturday, April 18, 2009

Jewish legacy inscribed on genes?

Ashkenazi Jews have a higher rate of some deadly genetic diseases -- and of high IQs. Scientists Gregory Cochran and Henry Harpending say that's no coincidence.

By Karen Kaplan
LA Times
April 18, 2009

Gregory Cochran has always been drawn to puzzles. This one had been gnawing at him for several years: Why are European Jews prone to so many deadly genetic diseases?

Tay-Sachs disease. Canavan disease. More than a dozen more.

It offended Cochran's sense of logic. Natural selection, the self-taught genetics buff knew, should flush dangerous DNA from the gene pool. Perhaps the mutations causing these diseases had some other, beneficial purpose. But what?

At 3:17 one morning, after a long night searching a database of scientific journals from his disheveled home office in Albuquerque, Cochran fired off an e-mail to his collaborator Henry Harpending, a distinguished professor of anthropology at the University of Utah in Salt Lake City and a member of the National Academy of Sciences.

(More here.)

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