SMRs and AMRs

Thursday, July 31, 2008

Drugs Offer Promise of Fitness Without Effort

By NICHOLAS WADE
NYT

Can you enjoy the benefits of exercise without the pain of exertion? The answer may one day be yes — just take a pill that tricks the muscles into thinking they have been working out furiously.

Researchers at the Salk Institute report they have found two drugs that do wonders for the athletic endurance of couch potato mice. One drug, known as Aicar, increased the mice’s endurance on a treadmill by 44 percent after just four weeks of treatment.

A second drug, GW1516, supercharged the mice to a 75 percent increase in endurance, but had to be combined with exercise to have any effect.

“It’s a little bit like a free lunch without the calories,” said Dr. Ronald M. Evans, leader of the Salk group.

(Continued here.)

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